Register

Register for the eventRegister yourself and a team online now

Download a Brochure

Download the brochureDownload the Cool Chain 2009 Brochure

Join Now!

linkedin
Join our Linkedin group

Newsletter Sign-Up

Become a Pharma IQ member to receive our newsletter!

Poll

Which industry do you think has the strictest, challenging technical hurdles in maintaining temperatures?

Food
Biotech
Vaccines
Medical Device
Pharmaceuticals

Testimonials

Very valuable: great platform to exchange information and thoughts to vendors and business colleagues.
John van den Ender, Amgen Europe BV

January 27 - 29, 2009 • Sheraton Brussels Airport Hotel and Conference Centre, Brussels, Belgium



Conference Day One: Wednesday, 28th January, 2009

8.00 Registration And Morning Coffee

8.45 Pharma IQ Welcome

8.50 Opening Remarks From Conference Chair

Dr. Rafik H. Bishara
Technical Advisor and Chair of Pharmaceutical Cold Chain Interest Group (PCCIG) USA Branch
PDA

9.00 Understanding And Complying With MHRA Guidelines

  • Shipping according to label claim: The regulatory position on variances and mixed shipments
  • What if there is no stability data?
  • Temperature deviations: Practical considerations and staying in compliance
  • Where do regulators stand on energy efficiency measures?

Ian Holloway
Manager, Defective Medicines Reporting Centre
MHRA

09.45 Aligning Cool Chain Initiatives Across Industry And Partners

  • New initiatives by the PCCIG: Including ‘Last Miles’ Task Force
  • Highlighting some feedback to elements of Technical Report 39 that requires clarification
  • Underlining the importance of partnerships to ensure effective, world-wide cool chain operations
  • QA developments in the Cool Chain: In an effort to work towards developing more robust quality management systems

Dr. Rafik H. Bishara
Technical Advisor and Chair Pharmaceutical Cold Chain Interest Group (PCCIG) USA Branch
PDA

10.30 Morning Refreshments And Networking Break

11.00 Developing A Master Quality Agreement For Cool Chain Partners: Setting And Communicating Expectations

  • ICH Q10 interpretation and inclusion into cool chain partner agreements
  • Defining the responsibilities and communication processes for quality related activities of suppliers
  • Streamlining quality agreements across transportation partners
  • Developing quality agreement templates for qualification of supply chain partners
  • Minimising human error and risks with several handovers by establishing an effective quality programme with updated contractual agreements
  • Outlining necessary and useful KPIs in an effective quality agreement
  • Measuring KPIs and putting a value on each (weighted/tiered approach)
  • Tracking and communicating KPIs and keeping partners accountable (quality business reviews, QBRs)
  • Monitoring incoming materials to ensure quality operations

David A Ulrich
QA Distribution Director, Global Pharmaceutical Operations (GPO), Strategic Quality Initiatives (SQI)
Abbott Laboratories

11.45 Panel Discussion: ‘Ask The Regulator’ How To Interpret And Implement European Regulations On Cold Chain

Transport of Biopharmaceuticals

(Anonymous questions may be submitted to the panel beforehand by sending to courtney.becker@iqpc.co.uk)

  • How are companies justifying their actions and validation plans to regulators?
  • Regulators advise they want to see more control over the cold chain – but what exactly will demonstrate this?

All morning speakers and participants are invited to join the discussion

12.45 Networking Lunch

Track A
Cool Investigational Medicinal Products

Track B
Cool Chain Logistics and Transportation

14.00 Development Of Cold Chain Containers For Investigational Medicinal Products

  • Evaluating business needs to transporting cold clinical supplies
  • NOEX vs. ALEX: a no excursion container vs. a container that allows minor deviations
  • Evaluating cost, efficiency and sophistication of containers for IMPs: Two-To-Eight (TTE) and the Courier Cold Shipper (CCS)
  • Problems encountered in practical use of containers
  • Estimating costs vs. value and efficiency of cold chain packaging

Dr Peter Kulmburg
Head of Global Quality Assurance TR&D
F. Hoffmann La Roche AG

14.40 Cold Chain Distribution Of Clinical Supplies Case Study: Efficient Distribution Supplies Around The Globe

  • Identifying weaknesses and gaps in clinical supply chain
  • Improving stability studies and gathering enough data to ensure process improvements
  • Managing excursions for clinical distributions
  • Implementing quality control standards for each distribution link
Franco Pasquale
Senior Manager of Manufacturing Collaborations
Genentech
Rognvald Lamb
EMEA Logistics Manager
Fisher Clinical Services

15.20 Developing Sufficient Stability Data To Maximise Label Conditions For Shipping And Storage Of Clinical Materials

  • Merging stability guidelines to streamline world wide quality initiatives
  • Making stability information available worldwide to scientists
  • Using stability data to maximise label conditions to allow for optimal temperature excursions

All participants of this afternoon are invited to join this discussion

16.00 Networking Break

14.00 Human Plasma Case Study: Transportation And Validation Via Land, Sea And Air

  • Fundamentals of transport validation is transport equal to mobile storage?
  • Comparison between airfreight (short passive cooled transports) vs. sea freight (long active cooled transports)
  • Weaknesses and strengths of systems and advantages and disadvantages of certain methods
  • Transportation monitoring, validation or both?
  • Monitoring positions from integrated sensors and product storage places
  • Interpretation of recorded data
  • Handling error / failures or off-limit conditions

Oliver Gross
QA Manager
ZLB Plasma

14.40 Optimising Cold Chain Logistics By Implementing Cost-Containment And Environmental Improvements

  • Maximising transportation volume per shipment to get a “green” result
  • Choosing the right security level and risk assessments
  • Evaluating if a ‘re-usable’ packaging concept works in your logistics strategy
  • How to re-write and check your specifications
  • Is your logistics management ready to progress and follow the evolution year by year?

Gilles Labranque
Chairman and Managing Director
Sofrigam

15.20 Improving Transportation Processes And Product Integrity With 3PL Partners

  • Identifying weak links in the distribution process measured by temperature deviations
  • Educating Freight Forwarders, Airlines and 3PLs on GXP cold chain practices
  • Defining, communicating and implementing shipping guidelines and working procedures
  • Measuring the performance of 3PLs to effectively monitor temperatures and reduce human error
  • Lessons learned in how to improve relationships and the outcome with transportation partners

Jim Bacon
Director, Global Demand Planning and Customer Operations
Talecris Biotherapeutics

16.00 Networking Break

16.30 Roundtable Discussions

After a full day of presentations, it’s time for all participants to take an active role and get answers to specific questions. These informal discussions will provide an opportunity to exchange ideas related specifically to job functions and interests. Facilitators will present a short case study as an introduction to the 60 minute discussion and question session.

A: Modern Modes of Cold Chain Transport: Weighing Cost, Compliance, Control and Capabilities

B: Security Challenges and Tools for the Cool Chain

C: Weighing Cost/Benefit vs. Value of Green Packaging Solutions and Strategies for your Cold Chain

D: Investing in Training and Building a Skill-based Work Force to Decrease Turnover and Failed Shipments

E: Shipping ‘Living’ Biological Materials with Cryogenic Technology and Implementing Speciality Logistics for Large Molecule Drugs

F: Understanding What Temperature Excursions are Allowable and Where to Put in the Regulatory File

G: Improving Airline Logistics and Controlling Temperatures in the Air: IATA Developments

H: Ambient Shipping Justification and Requirements vs. ICH Stability

I: Ensuring Product Integrity Through to the “Last Miles” of the Cool Chain

J: Cold Medical Devices: Assessing Packaging Limitations and Transportation Solutions

17.30 Summary Of Roundtable Discussions

18.15 Closing Remarks From Chairperson

18.20 Networking Drinks Reception

19.30 Cool Chain Europe Dinner And Excellence Awards

To recognise a colleague’s achievements, to nominate a colleague for one of the CCE Awards:

  • Most Influential Team, Person, Organisation or Project
  • Top Technology Provider of the Year
  • Best Service Provider of the Year

Dinner Keynote Address

20.00 Overcoming Current And Future Challenges Getting Vaccines To Remote Populations: Why The Cold Chain Matters So Much

  • Statistics on improved healthcare: Why the cold chain matters
  • Describing the challenges of the last miles of the vaccines supply chain today and in the coming years
  • Defining the technology, systems and ingenuity needed to get life-saving vaccines to remote populations
  • Working together to make a difference and utilising collaborations with Ministries of Health, WHO and NGO’s
  • How pharmaceutical manufacturers can help

Dr. Michel Zaffran
Senior Advisor
World Health Organization and Director of Project Optimize